منابع مشابه
Corrigendum: A melanosomal two-pore sodium channel regulates pigmentation
Corrigendum: A melanosomal two-pore sodium channel regulates pigmentation Nicholas W. Bellono, Iliana E. Escobar & Elena Oancea Scientific Reports 6:26570; doi: 10.1038/srep26570; published online 27 May 2016; updated 30 August 2016 This Article contains an error in Figure 4a: the upper right “hTPC2 rescue” trace is a duplication of the upper left “control” trace. The correct Figure 4 appears b...
متن کاملA melanosomal two-pore sodium channel regulates pigmentation
Intracellular organelles mediate complex cellular functions that often require ion transport across their membranes. Melanosomes are organelles responsible for the synthesis of the major mammalian pigment melanin. Defects in melanin synthesis result in pigmentation defects, visual deficits, and increased susceptibility to skin and eye cancers. Although genes encoding putative melanosomal ion tr...
متن کاملCharacterization of Two-Pore Channel 2 by Nuclear Membrane Electrophysiology
Lysosomal calcium (Ca(2+)) release mediated by NAADP triggers signalling cascades that regulate many cellular processes. The identification of two-pore channel 2 (TPC2) as the NAADP receptor advances our understanding of lysosomal Ca(2+) signalling, yet the lysosome is not amenable to traditional patch-clamp electrophysiology. Previous attempts to record TPC2 single-channel activity put TPC2 ou...
متن کاملPoring over furrows
Cryo-electron microscopy reveals the structure of a chloride channel that is closely related to a protein that transports lipids.
متن کاملPoring over exosome structure.
almost all rNa molecules are pro cessed by rNases to form mature rNas. in addition, many rNas are degraded, either because they are no longer needed or because they are aberrant. all of these functions—rNa processing, normal rNa degradation and rNa quality con trol—are carried out by the eukaryotic rNa exosome complex. in this issue of EMBO reports, the Lorentzen group provide struc tural in...
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ژورنال
عنوان ژورنال: Messenger
سال: 2015
ISSN: 2167-955X,2167-9568
DOI: 10.1166/msr.2015.1044